Effect of burdock extract on physical performance and physiological fatigue in mice

نویسندگان

  • Wen-Chyuan CHEN
  • Yi-Ju HSU
  • Mon-Chien LEE
  • Hua Shuai LI
  • Chun-Sheng HO
  • Chi-Chang HUANG
  • Fu-An CHEN
چکیده

Burdock (BD) is a common vegetable with many pharmacological properties. However, few studies have examined the effect of BD on exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effects of BD on fatigue and ergogenic functions following physical challenge in mice. METHODS Male ICR mice were divided into four groups to receive either vehicle, or BD at 348.5, 697 or 1,742.5 mg/kg/day, by daily oral gavage for 4 weeks. Exercise performance and fatigue were evaluated from forelimb grip strength, exhaustive swimming time, and post-exercise levels of physical fatigue-related biomarkers serum lactate, ammonia, glucose, and creatine kinase (CK). RESULTS BD supplementation elevated endurance and grip strength in a dose-dependent manner. It also significantly decreased lactate, ammonia, and CK levels after physical challenge. In addition, BD supplementation had few subchronic toxic effects. CONCLUSIONS Supplementation with BD has a wide spectrum of bioactive effects, including health promotion, performance improvement, and fatigue reduction.

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عنوان ژورنال:

دوره 79  شماره 

صفحات  -

تاریخ انتشار 2017